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Drugs that belong to the course of sedatives, sleep-inducing prescription drugs and anticonvulsants applied in the administration of epilepsy and in the procedure of irregular heart rhythms can hamper the performance of Levonorgestrel. These medicines are: barbiturates, phenytoin, such as primidon, carbamazepine, prescription drugs that contains hypericum in their components (Hypericum perforatum), rifampicin, ritonavir, rifabutin, griseofulvin. Medications that incorporate Levonorgestrel may increase toxicity of cyclosporine.

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